SnapShot: Class I PI3K Isoform Signaling

SnapShot: Class I PI3K Isoform Signaling

PTEN Regulates PI(3,4)P2 Signaling Downstream of Class I PI3K

The PI3K signaling pathway regulates cell growth and movement and is heavily mutated in cancer. Class I PI3Ks synthesize the lipid messenger PI(3,4,5)P3. PI(3,4,5)P3 can be dephosphorylated by 3- or 5-phosphatases, the latter producing PI(3,4)P2. The PTEN tumor suppressor is thought to function primarily as a PI(3,4,5)P3 3-phosphatase, limiting activation of this pathway. Here we show that PTEN...

SnapShot: p38 MAPK Signaling

SnapShot: PTEN Signaling Pathways

SnapShot: Hedgehog Signaling Pathway